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KMID : 0811720140180060469
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Korean Journal of Physiology & Pharmacology
2014 Volume.18 No. 6 p.469 ~ p.474
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Alcohol-induced Hyperlipidemia Is Ameliorated by Orally Administered DWP208, a Sodium Succinate Form of ZYM201
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Cho Jae-Youl
Choi Jong-Won
Park Jae-Gwang
Yi Young-Su
Hossen Muhammad Jahangir
Kim Hyeong-Min
Ro Ji-Eun
Cha Bae-Cheon
Yoo Eun-Sook
Kim Jong-Hoon
Lee Jae-Hwi
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Abstract
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DWP208 is a sodium succinate form of ZYM-201 which is a triterpenoid glycoside isolated from Sanguisorba officinalis, a medicinal plant prescribed for various diseases, such as duodenal ulcers and bleeding in East Asian counties. We demonstrated that this compound is able to normalize the altered lipid metabolism induced by hyperglycemia and a high fat diet. In this study, we determined whether hyperlipidemic conditions induced with chronically treated alcohol can also be restored by DWP208. Similar to our previous results, orally administered DWP208 (1 to 10 mg/kg) also ameliorated the hyperlipidemia that was induced by alcohol. This compound reversed the alcohol-induced hyper-lipidemia including (i) up-regulated hyperlipidemic parameters such as low-density lipoprotein (LDL), very low-density lipoprotein (VLDL), atherosclerotic index (AI), triglyceride, and total cholesterol, and (ii) down-regulated hyperlipidemic parameters such as absolute body weight, superoxide dismutase (SOD) activity, and high-density lipoprotein (HDL) in serum and liver. According to our data, the ameliorative activity of DWP208 is due to its indirect anti-oxidative activity as a result of which lipid peroxide and hydroxyl radical levels were reduced and the activity of SOD was enhanced. Therefore, our data strongly suggest that DWP208 can be used as a remedy against alcohol-induced hyper-lipidemia.
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KEYWORD
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Anti-hyperlipidemic activity, Chronic alcohol treatment, DWP208, Sanguisorba officinalis, Triterpenoid glycoside
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